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HPMC Capsule Shells

Empty cellulose capsule shells are nontoxic vegetarian capsule shells which are manufactured from Non animal origin material HPMC. HPMC is widely used in food and pharmaceutical industry as an additive, and are included in monographs of many pharmacopoeia like IP,USP,Ph.Eur HPMC are approved by FDA and EMA as food additive for direct or indirect applications.

WHO-JECFA database has no limits on the amount of HPMC intake.

Unique Properties of HPMC Capsule Shells

Well Suited for Moisture Sensitive Formulations
The low moisture content of these capsules enhances its applications to:

  • Formulations that contain hygroscopic material including dry powder inhalers
  • Formulations with active ingredients that are moisture sensitive

Excellent Machinebility and Mechanical and chemical Stability
An exclusive capsule design coupled with elastic polymer structure enables high machines efficiency:
  • Extensive field testing on a wide array of capsule filling and blister packaging equipment confirm robust commercial performance
  • HPMC Capsule shells are not affected by moisture and chemicals .Even in low humidity environments they maintain their elasticity and ability to resist mechanical breakage
  • No adjustment is necessary for customers who use gelatin capsules in their operations


Resistance to cross Linking
With a well characterized and stable polymer structure HPMC capsule offer reduced potential for cross linking:

Globally Accepted formulation:
The non-animal components of the HPMC capsule formulation are accepted for pharmaceutical use in all major global markets.

Relaxation from regulatory documentation:
TSE certification is not required, reducing the resources required for regulatory filing and international shipping and customs documentation

A simpler approach yields a new dimension in performance:
The chemical simplicity of HPMC Capsules which contains just three primary components (HPMC, Carrageenan and water and colorants as desired) can yield important advantages.





Hypromellose cellulose or HPMC


Hypromellose (INN), short for Hydroxy Propyl Methyl Cellulose. HPMC is solely plant based and free of animal products.

Hypromellose is a solid, and is a slightly off-white to beige powder in appearance and may be formed into granules. The compound forms colloids when dissolved in water. This non-toxic ingredient is combustible and can react vigorously with oxidizing agents.

Hypromellose in an aqueous solution, unlike methylcellulose, exhibits a thermal gelation property. That is, when the solution heats up to a critical temperature, the solution congeals into a non-flowable but semi-flexible mass. Typically, this critical (congealing) temperature is inversely related to both the solution concentration of HPMC and the concentration of the methoxy group within the HPMC molecule (which in turn depends on both the degree of substitution of the methoxy group and the molar substitution. That is, the higher the concentration of the methoxy group, the lower the critical temperature. The viscosity of the resulting mass, however, is directly related to the concentration of the methoxy group.

Names
Other names Hydroxypropyl methylcellulose; hydroxypropyl methyl cellulose; HPMC; E464
Identifiers
CAS Number 9004-65-3
ATC Code S01KA02
ChemSpider 21241863
UNII 36SFW2JZ0W
Properties
Chemical formula variable
Molar mass variable


Kappa Carrageenan
Kappa Carrageenan is a hydrocolloid extracted from some red seaweeds belonging to the Gigartina, Hypnea, Eucheuma, Chondrus and Iridaea species. It is used in a wide variety of applications in the food and pharmaceuticals industry as a thickening, gelling, stabilizing and suspending agent in water and milk systems.

Carrageenan has a unique ability to form a wide variety of gel textures at room temperature: rigid or elastic, clear or turbid, tough or tender, heat stable or thermally reversible, low or high melting/gelling temperatures. It may also be used as a suspending, gelling, emulsifying, stabilizing and water retaining agent in other industrial applications.



Avaiable Sizes of HPMC Capsule Shells


We manufactured Empty Hard HPMC Capsules in following sizes.

  • Size "00"
  • Size "0'
  • Size "1"
  • Size "2'
  • Size "3"
  • Size "4"





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