Hypromellose cellulose or HPMC

Hypromellose (INN), short for Hydroxy Propyl Methyl Cellulose. HPMC is solely plant based and free of animal products.

Hypromellose is a solid, and is a slightly off-white to beige powder in appearance and may be formed into granules. The compound forms colloids when dissolved in water. This non-toxic ingredient is combustible and can react vigorously with oxidizing agents.

Hypromellose in an aqueous solution, unlike methylcellulose, exhibits a thermal gelation property. That is, when the solution heats up to a critical temperature, the solution congeals into a non-flowable but semi-flexible mass. Typically, this critical (congealing) temperature is inversely related to both the solution concentration of HPMC and the concentration of the methoxy group within the HPMC molecule (which in turn depends on both the degree of substitution of the methoxy group and the molar substitution. That is, the higher the concentration of the methoxy group, the lower the critical temperature. The viscosity of the resulting mass, however, is directly related to the concentration of the methoxy group.

hard gelatin capsules

Kappa Carrageenan

Kappa Carrageenan is a hydrocolloid extracted from some red seaweeds belonging to the Gigartina, Hypnea, Eucheuma, Chondrus and Iridaea species. It is used in a wide variety of applications in the food and pharmaceuticals industry as a thickening, gelling, stabilizing and suspending agent in water and milk systems.

Carrageenan has a unique ability to form a wide variety of gel textures at room temperature: rigid or elastic, clear or turbid, tough or tender, heat stable or thermally reversible, low or high melting/gelling temperatures. It may also be used as a suspending, gelling, emulsifying, stabilizing and water retaining agent in other industrial applications.

Other names Hydroxypropyl methylcellulose; hydroxypropyl methyl cellulose; HPMC; E464
CAS Number 9004-65-3
ATC Code S01KA02
ChemSpider 21241863
Chemical formula variable
Molar mass variable